منابع مشابه
Engineering light-gated ion channels.
Ion channels are gated by a variety of stimuli, including ligands, voltage, membrane tension, temperature, and even light. Natural gates can be altered and augmented using synthetic chemistry and molecular biology to develop channels with completely new functional properties. Light-sensitive channels are particularly attractive because optical manipulation offers a high degree of spatial and te...
متن کاملReceptor-regulated ion channels.
Recent advances in the study of receptor-regulated ion channels include the cloning of the genes encoding three types of potassium channel that are favorite targets of receptors for transmitters and hormones. Studies of these channels have also provided a strong indication that G-protein betagamma subunits may gate ion channels via direct protein-protein interactions. Similarities between chann...
متن کاملLight-regulated ion transport through artificial ion channels based on TiO2 nanotubular arrays.
Light-responsive artificial ion channels are created using self-organized TiO(2) nanotubular arrays, whose ion transport properties can be regulated by external ultraviolet light. The formation of electrostatic traps within TiO(2) nanotubes by UV light contributes to the light-regulated ion transport.
متن کاملCyclic Nucleotide-Regulated Ion Channels: From Light Sensing to Pace Keeping
The cyclic nucleotide-regulated ion channels are a heterogeneous superfamily of different ion channels that share common membrane topology and pore structure and display a cyclic nucleotide-binding domain in their C-terminal region. Members of this superfamily include cyclic nucleotide-gated (CNG) cation channels, hyperpolarizationactivated cyclic nucleotide-gated (HCN) cation channels and also...
متن کاملO 13: Ion Channels in Autoimmune Neurodegeneration
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system characterized by widespread inflammation, focal demyelination and a variable degree of axonal and neuronal loss. Ionic conductances regulate T cell activation as well as neuronal function and thus have been found to play a crucial role in MS pathogenesis. Since present therapeutical approaches are only parti...
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ژورنال
عنوان ژورنال: Cold Spring Harbor Protocols
سال: 2011
ISSN: 1559-6095
DOI: 10.1101/pdb.top112